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The stalks and seeds have "much lower THC levels". After revisions to cannabis scheduling in the UK, the government moved cannabis back from a class C to a class B drug.

A purported reason was the appearance of high potency cannabis. Marijuana or marihuana herbal cannabis , [] consists of the dried flowers and subtending leaves and stems of the female Cannabis plant.

Although herbal cannabis and industrial hemp derive from the same species and contain the psychoactive component THC , they are distinct strains with unique biochemical compositions and uses.

Hemp has lower concentrations of THC and higher concentrations of CBD, which decreases the psychoactive effects [] []. Kief is a powder, rich in trichomes , [] which can be sifted from the leaves and flowers of cannabis plants and either consumed in powder form or compressed to produce cakes of hashish.

Hashish also spelled hasheesh, hashisha, or simply hash is a concentrated resin cake or ball produced from pressed kief, the detached trichomes and fine material that falls off cannabis flowers and leaves.

It varies in color from black to golden brown depending upon purity and variety of cultivar it was obtained from. Cannabinoids can be extracted from cannabis plant matter using high- proof spirits often grain alcohol to create a tincture , often referred to as "green dragon".

Hash oil is a resinous matrix of cannabinoids obtained from the Cannabis plant by solvent extraction , [] formed into a hardened or viscous mass.

There are many varieties of cannabis infusions owing to the variety of non-volatile solvents used. Examples of solvents used in this process are cocoa butter, dairy butter, cooking oil, glycerine , and skin moisturizers.

Depending on the solvent, these may be used in cannabis foods or applied topically. Medical marijuana refers to the use of the Cannabis plant as a physician-recommended herbal therapy as well as synthetic [] THC and cannabinoids.

So far, the medical use of cannabis is legal only in a limited number of territories, including Canada, [37] Belgium , Australia, the Netherlands , Spain, and many U.

This usage generally requires a prescription, and distribution is usually done within a framework defined by local laws.

There is evidence supporting the use of cannabis or its derivatives in the treatment of chemotherapy-induced nausea and vomiting, neuropathic pain, and multiple sclerosis.

Lower levels of evidence support its use for AIDS wasting syndrome, epilepsy, rheumatoid arthritis, and glaucoma.

Cannabis is indigenous to Central Asia [] and the Indian subcontinent, [] and its use for fabric and rope dates back to the Neolithic age in China and Japan.

Cannabis was known to the ancient Assyrians , who discovered its psychoactive properties through the Iranians. Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world.

Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus.

AD were found to have traces of cannabis. Cannabis was criminalized in various countries beginning in the 19th century.

The British colonies of Mauritius banned cannabis in over concerns on its effect on Indian indentured workers; [] the same occurred in British Singapore in In , a compromise was made at an international conference in The Hague about the International Opium Convention that banned exportation of "Indian hemp" to countries that had prohibited its use, and requiring importing countries to issue certificates approving the importation and stating that the shipment was required "exclusively for medical or scientific purposes".

It also required parties to "exercise an effective control of such a nature as to prevent the illicit international traffic in Indian hemp and especially in the resin".

In , the Dutch government divided drugs into more- and less-dangerous categories, with cannabis being in the lesser category. Accordingly, possession of 30 grams or less was made a misdemeanor.

Other types of sales and transportation are not permitted, although the general approach toward cannabis was lenient even before official decriminalisation.

In Uruguay, President Jose Mujica signed legislation to legalize recreational cannabis in December , making Uruguay the first country in the modern era to legalize cannabis.

In August , Uruguay legalized growing up to six plants at home, as well as the formation of growing clubs, and a state-controlled marijuana dispensary regime.

As of October 17, when recreational use of cannabis was legalized in Canada, dietary supplements for human use and veterinary health products containing not more than 10 parts per million of THC extract were approved for marketing; Nabiximols as Sativex is used as a prescription drug in Canada.

Since the beginning of the 20th century, most countries have enacted laws against the cultivation, possession or transfer of cannabis.

Many jurisdictions have lessened the penalties for possession of small quantities of cannabis so that it is punished by confiscation and sometimes a fine, rather than imprisonment, focusing more on those who traffic the drug on the black market.

In some areas where cannabis use had been historically tolerated, new restrictions were instituted, such as the closing of cannabis coffee shops near the borders of the Netherlands, [] and closing of coffee shops near secondary schools in the Netherlands.

Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution.

In December , the U. At least cities across California have enacted bans in recent years. In December , Uruguay became the first country to legalize growing, sale and use of cannabis.

In November , Uttarakhand became the first state of India to legalize the cultivation of hemp for industrial purposes. On October 17, , Australian health minister Sussan Ley presented a new law that will allow the cultivation of cannabis for scientific research and medical trials on patients.

As the drug has increasingly come to be seen as a health issue instead of criminal behavior, marijuana has also been legalized or decriminalized in: Between and , eleven states decriminalized marijuana.

In the US, men are over twice as likely to use marijuana as women and year-olds are six times more likely to use as over year-olds. Marijuana use in the United States is three times above the global average, but in line with other Western democracies.

However, potent seedless cannabis such as " Thai sticks " were already available at that time. Sinsemilla Spanish for "without seed" is the dried, seedless inflorescences of female cannabis plants.

Because THC production drops off once pollination occurs, the male plants which produce little THC themselves are eliminated before they shed pollen to prevent pollination.

Advanced cultivation techniques such as hydroponics , cloning , high-intensity artificial lighting , and the sea of green method are frequently employed as a response in part to prohibition enforcement efforts that make outdoor cultivation more risky.

It is often cited that the average levels of THC in cannabis sold in the United States rose dramatically between the s and , but such statements are likely skewed because undue weight is given to much more expensive and potent, but less prevalent samples.

It is a cross-breed of Cannabis sativa and C. The price or street value of cannabis varies widely depending on geographic area and potency.

The Gateway Hypothesis states that cannabis use increases the probability of trying "harder" drugs. The hypothesis has been hotly debated as it is regarded by some as the primary rationale for the United States prohibition on cannabis use.

Some studies state that while there is no proof for the gateway hypothesis, [] young cannabis users should still be considered as a risk group for intervention programs.

The gateway effect may appear due to social factors involved in using any illegal drug. Because of the illegal status of cannabis, its consumers are likely to find themselves in situations allowing them to acquaint with individuals using or selling other illegal drugs.

In turn alcohol and tobacco are easier to obtain at an earlier point than is cannabis though the reverse may be true in some areas , thus leading to the "gateway sequence" in those individuals since they are most likely to experiment with any drug offered.

An alternative to the gateway hypothesis is the common liability to addiction CLA theory. It states that some individuals are, for various reasons, willing to try multiple recreational substances.

The "gateway" drugs are merely those that are usually available at an earlier age than the harder drugs. Researchers have noted in an extensive review that it is dangerous to present the sequence of events described in gateway "theory" in causative terms as this hinders both research and intervention.

Cannabis research is challenging since the plant is illegal in most countries. There are also other difficulties in researching the effects of cannabis.

Many people who smoke cannabis also smoke tobacco. Another difficulty researchers have is in recruiting people who smoke cannabis into studies.

Because cannabis is an illegal drug in many countries, people may be reluctant to take part in research, and if they do agree to take part, they may not say how much cannabis they actually smoke.

A review found that the use of high CBD-to-THC strains of cannabis showed significantly fewer positive symptoms such as delusions and hallucinations, better cognitive function and both lower risk for developing psychosis, as well as a later age of onset of the illness, compared to cannabis with low CBD-to-THC ratios.

Cannabis use started to become popular in the United States in the s. Private use of cannabis was legalized in September after a unanimous decision by the Constitutional Court in Johannesburg.

Media related to Cannabis at Wikimedia Commons. From Wikipedia, the free encyclopedia. Cannabis A flowering cannabis plant. Medical cannabis from state-controlled production: Anlage III , other cannabis: Schedule I legal in 9 states for recreational use UN: Entheogenic use of cannabis.

Long-term effects of cannabis. History of cannabis and Timeline of cannabis. Prohibition of drugs and Drug liberalization. Illegal but often unenforced.

Marijuana and the Cannabinoids. Retrieved 13 December Retrieved 12 January Retrieved 28 September Retrieved 9 October Retrieved 17 July American Heritage Dictionary of the English Language.

See also article on Marijuana as a word. Spanish Word Histories and Mysteries: Pharmacology, Toxicology, and Therapeutic Potential.

National Institute on Drug Abuse. Retrieved 19 April Retrieved 12 July Manual of forensic emergency medicine: Jones and Bartlett Publishers. World Drug Report Retrieved 26 June Retrieved 9 September Retrieved 30 October National Conference of State Legislatures.

Retrieved 3 July Retrieved 19 October National Institute of Drug Abuse. The term medical marijuana refers to using the whole unprocessed marijuana plant or its basic extracts to treat a disease or symptom.

Retrieved 8 September A Systematic Review and Meta-analysis". Current Pain and Headache Reports. Archived from the original PDF on 30 April British Journal of Hospital Medicine.

Cannabis Use and Dependence: Public Health and Public Policy. Cannabis in Medical Practice: University of Virginia Medical Center. Cannabinoid function in learning, memory and plasticity.

Handbook of Experimental Pharmacology. Marijuana Cannabis sativa L. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants.

Retrieved 14 July The American Journal on Addictions. Retrieved 1 November Are All These Hoops Necessary? Brazilian Archives of Biology and Technology.

Drugs and the Making of the Modern World. Greater Than the Sum of Their Parts? Retrieved 7 April There is clear evidence that recreational cannabis can produce a transient toxic psychosis in larger doses or in susceptible individuals, which is said to characteristically resolve within a week or so of absence Johns European Archives of Psychiatry and Clinical Neuroscience.

Drug Abuse Warning Network. Department of Health and Human Services. Retrieved 8 May The New England Journal of Medicine.

Marijuana Use During Pregnancy and Lactation". Diagnosis, Pathophysiology, and Treatment-a Systematic Review".

Journal of Medical Toxicology. Drug Use and Abuse. Archives of Internal Medicine. Archived from the original on Annals of the American Thoracic Society.

Pooled analysis in the International Lung Cancer Consortium". International Journal of Cancer. Archives of Oral Biology.

What the initial literature suggests regarding vapourized cannabis and respiratory risk". Canadian Journal of Respiratory Therapy. Comorbidity of Mental and Physical Disorders.

Karger Medical and Scientific Publishers. Annals of Internal Medicine. Clinical Pharmacology and Therapeutics. Journal of Addiction Medicine.

The American Journal of Cardiology. Journal of Clinical Pharmacology Review. A meta-analytical review of structural brain alterations in non-psychotic users".

Psychiatry and Clinical Neurosciences. The most consistently reported brain alteration was reduced hippocampal volume which was shown to persist even after several months of abstinence in one study and also to be related to the amount of cannabis use Other frequently reported morphological brain alterations related to chronic cannabis use were reported in the amygdala the cerebellum and the frontal cortex These findings may be interpreted as reflecting neuroadaptation, perhaps indicating the recruitment of additional regions as a compensatory mechanism to maintain normal cognitive performance in response to chronic cannabis exposure, particularly within the prefrontal cortex area.

Evidence from Studies of Adult Users". Neuroscience and Biobehavioral Reviews. This may reflect the multitude of cognitive tasks employed by the various studies included in these meta-analyses, all of which involved performing a task thereby requiring the participant to reorient their attention and attempt to solve the problem at hand and suggest that greater engagement of this region indicates less efficient cognitive performance in cannabis users in general, irrespective of their age.

Cannabis, cognition and addiction" PDF. Journal of Neuroimmune Pharmacology. A systematic review of human and animal evidence".

Experimental and Clinical Psychopharmacology. Therefore, results indicate evidence for small neurocognitive effects that persist after the period of acute intoxication As hypothesized, the meta-analysis conducted on studies eval- uating users after at least 25 days of abstention found no residual effects on cognitive performance These results fail to support the idea that heavy cannabis use may result in long-term, persistent effects on neuropsychological functioning.

Journal of Clinical Pharmacology. Cannabis appears to continue to exert impairing effects in executive functions even after 3 weeks of abstinence and beyond.

While basic attentional and working memory abilities are largely restored, the most enduring and detectable deficits are seen in decision-making, concept formation and planning.

Archives of General Psychiatry. The International Journal on Drug Policy. Method development, drug distribution and interpretation of results".

Journal of Analytical Toxicology. Para-halogenated amphetamines and pyrovalerone cathinones". A promising class of monoamine uptake inhibitors".

Journal of Medicinal Chemistry. Acquisition of self-administration and fixed ratio dose-response curves in rats".

Archived from the original on Retrieved 3 December Disposition of toxic drugs and chemicals in man. Retrieved September 29, China Food and Drug Administration.

Retrieved 1 October Archived from the original PDF on The Sydney Morning Herald. Retrieved November 11, Adapromine Amantadine Bromantane Memantine Rimantadine.

Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide.

China Food and Drug Administration. Retrieved 1 October Archived from the original PDF on The Sydney Morning Herald.

Retrieved November 11, Adapromine Amantadine Bromantane Memantine Rimantadine. Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide.

Retrieved from " https: Designer drugs Norepinephrine-dopamine reuptake inhibitors Pyrrolidinophenones Stimulants. Views Read Edit View history.

This page was last edited on 28 January , at European Archives of Psychiatry and Clinical Neuroscience. Drug Abuse Warning Network.

Department of Health and Human Services. Retrieved 8 May The New England Journal of Medicine. Marijuana Use During Pregnancy and Lactation".

Diagnosis, Pathophysiology, and Treatment-a Systematic Review". Journal of Medical Toxicology. Drug Use and Abuse. Archives of Internal Medicine.

Archived from the original on Annals of the American Thoracic Society. Pooled analysis in the International Lung Cancer Consortium". International Journal of Cancer.

Archives of Oral Biology. What the initial literature suggests regarding vapourized cannabis and respiratory risk". Canadian Journal of Respiratory Therapy.

Comorbidity of Mental and Physical Disorders. Karger Medical and Scientific Publishers. Annals of Internal Medicine. Clinical Pharmacology and Therapeutics.

Journal of Addiction Medicine. The American Journal of Cardiology. Journal of Clinical Pharmacology Review. A meta-analytical review of structural brain alterations in non-psychotic users".

Psychiatry and Clinical Neurosciences. The most consistently reported brain alteration was reduced hippocampal volume which was shown to persist even after several months of abstinence in one study and also to be related to the amount of cannabis use Other frequently reported morphological brain alterations related to chronic cannabis use were reported in the amygdala the cerebellum and the frontal cortex These findings may be interpreted as reflecting neuroadaptation, perhaps indicating the recruitment of additional regions as a compensatory mechanism to maintain normal cognitive performance in response to chronic cannabis exposure, particularly within the prefrontal cortex area.

Evidence from Studies of Adult Users". Neuroscience and Biobehavioral Reviews. This may reflect the multitude of cognitive tasks employed by the various studies included in these meta-analyses, all of which involved performing a task thereby requiring the participant to reorient their attention and attempt to solve the problem at hand and suggest that greater engagement of this region indicates less efficient cognitive performance in cannabis users in general, irrespective of their age.

Cannabis, cognition and addiction" PDF. Journal of Neuroimmune Pharmacology. A systematic review of human and animal evidence".

Experimental and Clinical Psychopharmacology. Therefore, results indicate evidence for small neurocognitive effects that persist after the period of acute intoxication As hypothesized, the meta-analysis conducted on studies eval- uating users after at least 25 days of abstention found no residual effects on cognitive performance These results fail to support the idea that heavy cannabis use may result in long-term, persistent effects on neuropsychological functioning.

Journal of Clinical Pharmacology. Cannabis appears to continue to exert impairing effects in executive functions even after 3 weeks of abstinence and beyond.

While basic attentional and working memory abilities are largely restored, the most enduring and detectable deficits are seen in decision-making, concept formation and planning.

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Recreational and medical applications rights Industrial applications. Autoflowering cannabis Cannabis indica ruderalis sativa Difference between C.

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